Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia.

ABSTRACT:

Objective

Deficits in working memory and cognitive control in schizophrenia are associated with impairments in prefrontal cortical function, including altered gamma band oscillations. These abnormalities are thought to reflect a deficiency in the synchronization of pyramidal cell activity that is dependent, in part, on gamma-aminobutyric acid (GABA) neurotransmission through GABA type A (GABA(A)) receptors containing alpha(2) subunits. The authors conducted a proof-of-concept clinical trial designed to test the hypothesis that a novel compound with relatively selective agonist activity at GABA(A) receptors containing alpha(2) subunits would improve cognitive function and gamma band oscillations in individuals with schizophrenia.

Method

Participants were male subjects (N=15)

SUBMITTER: Lewis DA 

PROVIDER: S-EPMC2876339 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature