Association of pathogen strain-specific gene transcription and transmission efficiency phenotype of Anaplasma marginale.

ABSTRACT: Efficient transmission of pathogens by an arthropod vector is influenced by the ability of the pathogen to replicate and develop infectiousness within the arthropod host. While the basic life cycle of development within and transmission from the arthropod vector are known for many bacterial and protozoan pathogens, the determinants of transmission efficiency are largely unknown and represent a significant gap in our knowledge. The St. Maries strain of Anaplasma marginale is a high-transmission-efficiency strain that replicates to a high titer in the tick salivary gland and can be transmitted by <10 ticks. In contrast, A. marginale subsp. centrale (Israel vaccine strain) has an identical life cycle but replicates to a significantly lower level in the salivary gland, with transmission requir

SUBMITTER: Agnes JT 

PROVIDER: S-EPMC2876553 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature