Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.

ABSTRACT: Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13) or narrow (

SUBMITTER: Julg B 

PROVIDER: S-EPMC2876607 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature