The innate immune response affects the development of the autoimmune response in Theiler's virus-induced demyelinating disease.

ABSTRACT: Multiple sclerosis (MS) is a human CNS autoimmune demyelinating disease. Epidemiological evidence has suggested a role for virus infection in the initiation and/or exacerbation of MS. Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease serves as a relevant mouse model for MS. TMEV-infected mice develop a demyelinating disease with clinical symptoms beginning around 35 days after infection, which is associated with development of myelin-specific, PLP(139-151), CD4(+) T cell responses. Viruses have been suggested to initiate autoimmune disease through bystander activation of immune cells or through bystander damage to tissue during infection. We examined the effect of the innate immune response on development of autoimmune demyelinating disease by altering the innat

SUBMITTER: Olson JK 

PROVIDER: S-EPMC2876715 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature