A framework for classification of prokaryotic protein kinases.

ABSTRACT:

Background

Overwhelming majority of the Serine/Threonine protein kinases identified by gleaning archaeal and eubacterial genomes could not be classified into any of the well known Hanks and Hunter subfamilies of protein kinases. This is owing to the development of Hanks and Hunter classification scheme based on eukaryotic protein kinases which are highly divergent from their prokaryotic homologues. A large dataset of prokaryotic Serine/Threonine protein kinases recognized from genomes of prokaryotes have been used to develop a classification framework for prokaryotic Ser/Thr protein kinases.

Methodology/principal findings

We have used traditional sequence alignment and phylogenetic approaches and clustered the prokaryotic kinases which represent 72 subfamilies with at least

SUBMITTER: Tyagi N 

PROVIDER: S-EPMC2877116 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature