Genetic and environmental risks for high blood pressure among African American mothers and daughters.

ABSTRACT:

Objective

To determine the relationship between genetic and environmental lifestyle factors (physical activity and sodium) on blood pressure (BP) among African-American women.

Method

In this cross-sectional study involving 108 African-American mothers and daughters from a Midwestern area, investigators obtained BP measurements, information on minutes of physical activity, amount of sodium intake, and buccal swab saliva samples.

Results

Of the 4 single nucleotide polymorphisms (SNPs) on the sodium bicarbonate cotransporter gene (SLC4A5), rs8179526 had a statistically significant interaction with cytosine/thymine (C/T) genotype by sodium status on systolic BP (SBP; p=.0077). For gene x physical activity interaction, 2 significant interactions (cytosine/adenine [C/A] gen

SUBMITTER: Taylor JY 

PROVIDER: S-EPMC2877137 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature