Interplay between intrinsic noise and the stochasticity of the cell cycle in bacterial colonies.

ABSTRACT: Herein we report on the effects that different stochastic contributions induce in bacterial colonies in terms of protein concentration and production. In particular, we consider for what we believe to be the first time cell-to-cell diversity due to the unavoidable randomness of the cell-cycle duration and its interplay with other noise sources. To that end, we model a recent experimental setup that implements a protein dilution protocol by means of division events to characterize the gene regulatory function at the single cell level. This approach allows us to investigate the effect of different stochastic terms upon the total randomness experimentally reported for the gene regulatory function. In addition, we show that the interplay between intrinsic fluctuations and the stochasticity of

SUBMITTER: Canela-Xandri O 

PROVIDER: S-EPMC2877355 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature