Effect of trajectories of glycemic control on mortality in type 2 diabetes: a semiparametric joint modeling approach.

ABSTRACT: Data on the effect of trajectories in long-term glycemia and all-cause mortality are lacking. The authors studied the effect of trajectories in long-term glycemic control on all-cause mortality in patients with type 2 diabetes. A cohort of 8,812 veterans with type 2 diabetes was assembled retrospectively using Veterans Affairs registry data. For each veteran in the cohort, a 3-month person-period data set was created from April 1997 to May 2006. The average duration of follow-up was 4.5 years. The overall mortality rate was 15.3%. Using a novel approach for joint modeling of time to death and longitudinal measurements of hemoglobin A1c (HbA1c) level, after adjustment for all significant baseline covariates, baseline HbA1c was found to be significantly associated with mortality (hazard rati

SUBMITTER: Gebregziabher M 

PROVIDER: S-EPMC2877473 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature