A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis.

ABSTRACT:

Aims/hypothesis

Insulin-requiring diabetes affects 25-50% of young adults with cystic fibrosis (CF). Although the cause of diabetes in CF is unknown, recent heritability studies in CF twins and siblings indicate that genetic modifiers play a substantial role. We sought to assess whether genes conferring risk for diabetes in the general population may play a risk modifying role in CF.

Methods

We tested whether a family history of type 2 diabetes affected diabetes risk in CF patients in 539 families in the CF Twin and Sibling family-based study. A type 2 diabetes susceptibility gene (transcription factor 7-like 2, or TCF7L2) was evaluated for association with diabetes in CF using 998 patients from the family-based study and 802 unrelated CF patients in an independent case-cont

SUBMITTER: Blackman SM 

PROVIDER: S-EPMC2877501 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature