Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome.

ABSTRACT: The murine model for Turner Syndrome is the XO mouse. Unlike their human counterparts, XO mice are typically fertile, and their lack of a second sex chromosome can be transmitted from one generation to the next as an X-linked dominant trait with male lethality. The introduction of an X-linked coat-color marker (tabby) has greatly facilitated the maintenance of this useful mouse strain. XO mice can be produced in large numbers, generation after generation, and rapidly identified on the basis of their sex and coat color. Although this breeding scheme appears to be effective at the phenotype level, its utility has never been conclusively proved at the molecular or cytogenetic levels. Here, we clone and sequence the tabby deletion break point and present a multiplex polymerase chain reaction-b

SUBMITTER: Probst FJ 

PROVIDER: S-EPMC2877559 | biostudies-literature | 2008 Sep-Oct

REPOSITORIES: biostudies-literature