Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome.

ABSTRACT: The replication of a chromosomal region during S phase can be highly dynamic between cell types that differ in transcriptome and epigenome. Early replication timing has been positively correlated with several histone modifications that occur at active genes, while repressive histone modifications mark late replicating regions. This raises the question if chromatin modulates the initiating events of replication. To gain insights into this question, we have studied the function of heterochromatin protein 1 (HP1), which is a reader of repressive methylation at histone H3 lysine 9, in genome-wide organization of replication. Cells with reduced levels of HP1 show an advanced replication timing of centromeric repeats in agreement with the model that repressive chromatin mediates the very late re

SUBMITTER: Schwaiger M 

PROVIDER: S-EPMC2877574 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature