Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.

ABSTRACT: Immature B cells migrate to the spleen where they differentiate into mature cells. This final maturation step is crucial to enable B cells to become responsive to antigens and to participate in the immune response. Previously, we showed that Id2 acts as a negative regulator of the differentiation of immature B cells occurring in the spleen. Id2 expression has been found to depend on Myc-Max-Mad transcriptional complexes in mammary epithelial cells. Nearly all studies to date have shown that Mad proteins inhibit proliferation, presumably by antagonizing the function of Myc proteins. In the current study, we followed the Mad family members during peripheral B cell differentiation. We show that Mad3 actively regulates B cell differentiation. Our results demonstrate that high expression levels

SUBMITTER: Gore Y 

PROVIDER: S-EPMC2877644 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature