Evaluating the transferability of Hapmap SNPs to a Singapore Chinese population.

ABSTRACT:

Background

The International Hapmap project serves as a valuable resource for human genome variation data, however its applicability to other populations has yet to be exhaustively investigated. In this paper, we use high density genotyping chips and resequencing strategies to compare the Singapore Chinese population with the Hapmap populations. First we compared 1028 and 114 unrelated Singapore Chinese samples genotyped using the Illumina Human Hapmap 550 k chip and Affymetrix 500 k array respectively against the 270 samples from Hapmap. Secondly, data from 20 candidate genes on 5q31-33 resequenced for an asthma candidate gene based study was also used for the analysis.

Results

A total of 237 SNPs were identified through resequencing of which only 95 SNPs (40%) were in Hapm

SUBMITTER: Andiappan AK 

PROVIDER: S-EPMC2877651 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature