The immunization-induced antibody response to the Anaplasma marginale major surface protein 2 and its association with protective immunity.

ABSTRACT: Many vector-borne pathogens evade clearance via rapid variation in their immunogenic surface expressed proteins. This is exemplified by Anaplasma marginale, a tick-borne bacterial pathogen that generates major surface protein 2 (Msp2) variants to provide for immune escape and allow long-term pathogen persistence. In contrast to persistence following infection, immunization with a surface protein complex, which includes Msp2, induces a response that prevents infection upon challenge. We hypothesized that the immune response induced by immunization altered the anti-Msp2 antibody repertoire as compared to that induced during infection, shifting the immune response toward conserved and thus broadly protective epitopes. The antibody response to the conserved (CR) and hypervariable (HVR) regions

SUBMITTER: Noh SM 

PROVIDER: S-EPMC2877794 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature