The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers.

ABSTRACT: Development of chemoresistance limits the clinical efficiency of platinum-based therapy. Although many resistance mechanisms have been demonstrated, genetic/molecular alterations responsible for drug resistance in the majority of clinical cases have not been identified. We analyzed three pairs of testicular germ cell tumor cell lines using Affymetrix expression microarrays and revealed a limited number of differentially expressed genes across the cell lines when comparing the parental and resistant cells. Among them, CCND1 was the most significantly differentially expressed gene. Analysis of testicular germ cell tumor clinical samples by quantitative reverse transcription PCR analysis revealed that overall expression of CCND1 was significantly higher in resistant cases compared with sensit

SUBMITTER: Noel EE 

PROVIDER: S-EPMC2877824 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature