Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans.

ABSTRACT: Identifying transplant recipients in whom immunological tolerance is established or is developing would allow an individually tailored approach to their posttransplantation management. In this study, we aimed to develop reliable and reproducible in vitro assays capable of detecting tolerance in renal transplant recipients. Several biomarkers and bioassays were screened on a training set that included 11 operationally tolerant renal transplant recipients, recipient groups following different immunosuppressive regimes, recipients undergoing chronic rejection, and healthy controls. Highly predictive assays were repeated on an independent test set that included 24 tolerant renal transplant recipients. Tolerant patients displayed an expansion of peripheral blood B and NK lymphocytes, fewer acti

SUBMITTER: Sagoo P 

PROVIDER: S-EPMC2877932 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature