Uric acid promotes an acute inflammatory response to sterile cell death in mice.

ABSTRACT: Necrosis stimulates inflammation, and this response is medically relevant because it contributes to the pathogenesis of a number of diseases. It is thought that necrosis stimulates inflammation because dying cells release proinflammatory molecules that are recognized by the immune system. However, relatively little is known about the molecular identity of these molecules and their contribution to responses in vivo. Here, we investigated the role of uric acid in the inflammatory response to necrotic cells in mice. We found that dead cells not only released intracellular stores of uric acid but also produced it in large amounts postmortem as nucleic acids were degraded. Using newly developed Tg mice that have reduced levels of uric acid either intracellularly and/or extracellularly, we found

SUBMITTER: Kono H 

PROVIDER: S-EPMC2877935 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature