Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.

ABSTRACT:

Purpose

Variants at chromosomal loci 8q24 and 17q are established risk factors for prostate cancer. Many studies have confirmed the findings for risk, but few have examined aggressiveness and other clinical variables in detail. Additionally, Gleason score is typically used as a surrogate for the primary end point of prostate cancer mortality. We investigated whether the 8q24 and 17q risk variants are associated with clinical variables as well as prostate cancer mortality.

Experimental design

In the Physicians' Health Study (1,347 cases and 1,462 controls), the Dana-Farber Harvard Cancer Center Specialized Program of Research Excellence (Gelb Center; 3,714 cases), and the Fred Hutchinson Cancer Research Center King County Case-Control Studies (1,308 cases and 1,266 controls),

SUBMITTER: Penney KL 

PROVIDER: S-EPMC2878092 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature