S100A12 mediates aortic wall remodeling and aortic aneurysm.

ABSTRACT:

Rationale

S100A12 is a small calcium binding protein that is a ligand of RAGE (receptor for advanced glycation end products). RAGE has been extensively implicated in inflammatory states such as atherosclerosis, but the role of S100A12 as its ligand is less clear.

Objective

To test the role of S100A12 in vascular inflammation, we generated and analyzed mice expressing human S100A12 in vascular smooth muscle under control of the smooth muscle 22alpha promoter because S100A12 is not present in mice.

Methods and results

Transgenic mice displayed pathological vascular remodeling with aberrant thickening of the aortic media, disarray of elastic fibers, and increased collagen deposition, together with increased latent matrix metalloproteinase-2 protein and reduction in smoot

SUBMITTER: Hofmann Bowman M 

PROVIDER: S-EPMC2878187 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature