Human abuse liability assessment of oxycodone combined with ultra-low-dose naltrexone.

ABSTRACT:

Rationale

Prescription opioid abuse has risen dramatically in the United States as clinicians have increased opioid prescribing for alleviation of both acute and chronic pain. Opioid analgesics with decreased risk for abuse are needed.

Objective

Preclinical and clinical studies have shown that opioids combined with ultra-low-dose naltrexone (NTX) may have increased analgesic potency and have suggested reduced abuse or dependence liability. This study addressed whether addition of ultra-low-dose naltrexone might decrease the abuse liability of oxycodone (OXY) in humans.

Materials and methods

This double-blind, placebo-controlled study systematically examined the subjective and physiological effects of combining oral OXY and ultra-low NTX doses in 14 experienced opioid

SUBMITTER: Tompkins DA 

PROVIDER: S-EPMC2878387 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature