Stereoselective additions of thiyl radicals to terminal ynamides.

ABSTRACT: Two complementary sets of conditions for radical additions of thiols to terminal ynamides are described. The use of 1 equiv of thiol affords the cis-beta-thioenamide adducts in rapid fashion (10 min) and good dr, whereas employing excess thiol and longer reaction times favors the trans products.

SUBMITTER: Banerjee B 

PROVIDER: S-EPMC2878391 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature