Conserved 3'-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons.

ABSTRACT: mRNA localization provides polarized cells with a locally renewable source of proteins. In neurons, mRNA translation can occur at millimeters to centimeters from the cell body, giving the dendritic and axonal processes a means to autonomously respond to their environment. Despite that hundreds of mRNAs have been detected in neuronal processes, there are no reliable means to predict mRNA localization elements. Here, we have asked what RNA elements are needed for localization of transcripts encoding endoplasmic reticulum chaperone proteins in neurons. The 3'-untranslated regions (UTRs) of calreticulin and Grp78/BiP mRNAs show no homology to one another, but each shows extensive regions of high sequence identity to their 3'UTRs in mammalian orthologs. These conserved regions are sufficient fo

SUBMITTER: Vuppalanchi D 

PROVIDER: S-EPMC2878564 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature