Enantioselective synthesis of (+)-isolysergol via ring-closing metathesis.

ABSTRACT: The first enantioselective synthesis of (+)-isolysergol was completed in 12 steps from commercially available materials by a novel approach that features a late stage microwave-mediated, diastereomeric ring-closing metathesis catalyzed by a chiral molybdenum catalyst to simultaneously form the D ring and set the stereocenter at C(8).

SUBMITTER: Deck JA 

PROVIDER: S-EPMC2879020 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature