Signal transduction molecules in gliomas of all grades.

ABSTRACT:

Purpose

To interrogate grade II, III, and IV gliomas and characterize the critical effectors within the PI3-kinase pathway upstream and downstream of mTOR. Experimental design Tissues from 87 patients who were treated at UCSF between 1990 and 2004 were analyzed. Twenty-eight grade II, 17 grade III glioma, 26 grade IV gliomas, and 16 non-tumor brain specimens were analyzed. Protein levels were assessed by immunoblots; RNA levels were determined by polymerase chain reaction amplification. To address the multiple comparisons, first an overall analysis was done comparing the four groups using Spearman's Correlation Coefficient. Only if this analysis was statistically significant were individual pairwise comparisons done.

Results

Multiple comparison analyses revealed a significan

SUBMITTER: Ermoian RP 

PROVIDER: S-EPMC2879130 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature