Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.

ABSTRACT:

Background and objectives

Diabetic nephropathy (DN) is a multifactorial complication characterized by persistent proteinuria in susceptible individuals with type 1 and type 2 diabetes. Disease burden in people of Mexican-American descent is particularly high, but there are only a few studies that characterize genes for DN in this ethnic group. Two genes, carnosine dipeptidase 1 (CNDP1) and engulfment and cell motility 1 (ELMO1) previously showed association with DN in other ethnic groups. CNDP1 and ELMO1 were examined along with eight other genes that are less well characterized for DN in a new study of Mexican-Americans.

Design, setting, participants, & measurements

The target sample was patients of Mexican-American ancestry collected from three centers: 455 patients with D

SUBMITTER: Kim S 

PROVIDER: S-EPMC2879299 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature