Overlapping splicing regulatory motifs--combinatorial effects on splicing.

ABSTRACT: Regulation of splicing in eukaryotes occurs through the coordinated action of multiple splicing factors. Exons and introns contain numerous putative binding sites for splicing regulatory proteins. Regulation of splicing is presumably achieved by the combinatorial output of the binding of splicing factors to the corresponding binding sites. Although putative regulatory sites often overlap, no extensive study has examined whether overlapping regulatory sequences provide yet another dimension to splicing regulation. Here we analyzed experimentally-identified splicing regulatory sequences using a computational method based on the natural distribution of nucleotides and splicing regulatory sequences. We uncovered positive and negative interplay between overlapping regulatory sequences. Examinat

SUBMITTER: Goren A 

PROVIDER: S-EPMC2879502 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature