Association between learning capabilities and practice-related activation changes in schizophrenia.

ABSTRACT: The present functional magnetic resonance imaging study investigated the neural correlates of practice-associated activation changes in patients with schizophrenia and their association with symptom severity. A group of patients (n = 24) were divided into more successful and less successful learners and were asked to perform a verbal overlearning task in the scanner. We found that both patient groups profited from practice, showing significant decreases in mean response times as well as significant learning-related decreases in cerebral activation. Direct comparison between groups yielded a relative hyperactivation in the group of the less successful learners at the beginning of practice, which showed a reduction with increasing practice. This was reflected by relatively stronger signal de

SUBMITTER: Koch K 

PROVIDER: S-EPMC2879680 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature