VitAL: Viterbi algorithm for de novo peptide design.

ABSTRACT:

Background

Drug design against proteins to cure various diseases has been studied for several years. Numerous design techniques were discovered for small organic molecules for specific protein targets. The specificity, toxicity and selectivity of small molecules are hard problems to solve. The use of peptide drugs enables a partial solution to the toxicity problem. There has been a wide interest in peptide design, but the design techniques of a specific and selective peptide inhibitor against a protein target have not yet been established.

Methodology/principal findings

A novel de novo peptide design approach is developed to block activities of disease related protein targets. No prior training, based on known peptides, is necessary. The method sequentially generates the pep

SUBMITTER: Unal EB 

PROVIDER: S-EPMC2880006 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature