Collagen XXIII: a potential biomarker for the detection of primary and recurrent non-small cell lung cancer.

ABSTRACT:

Background

Collagen XXIII is a transmembrane collagen previously shown to be upregulated in metastatic prostate cancer. The purpose of this study was to determine the protein expression of collagen XXIII in tumor tissues from a variety of cancers and to assess the utility of collagen XXIII as a biomarker for non-small cell lung cancer (NSCLC).

Methods

A multicancer tissue microarray was used for the immunohistochemical examination of collagen XXIII protein expression in a variety of cancers. Subsequently, collagen XXIII expression was analyzed in three separate cohorts using tissue microarrays with representative tumor and control lung tissues from NSCLC patients. In addition, NSCLC patient urine samples were analyzed for the presence of collagen XXIII through Western blot.<

SUBMITTER: Spivey KA 

PROVIDER: S-EPMC2880394 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature