Genome-wide analysis of regions similar to promoters of histone genes.

ABSTRACT:

Background

The purpose of this study is to: i) develop a computational model of promoters of human histone-encoding genes (shortly histone genes), an important class of genes that participate in various critical cellular processes, ii) use the model so developed to identify regions across the human genome that have similar structure as promoters of histone genes; such regions could represent potential genomic regulatory regions, e.g. promoters, of genes that may be coregulated with histone genes, and iii/ identify in this way genes that have high likelihood of being coregulated with the histone genes.

Results

We successfully developed a histone promoter model using a comprehensive collection of histone genes. Based on leave-one-out cross-validation test, the model produced g

SUBMITTER: Chowdhary R 

PROVIDER: S-EPMC2880410 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature