Gene expression profiling of peripheral blood cells for early detection of breast cancer.

ABSTRACT:

Introduction

Early detection of breast cancer is key to successful treatment and patient survival. We have previously reported the potential use of gene expression profiling of peripheral blood cells for early detection of breast cancer. The aim of the present study was to refine these findings using a larger sample size and a commercially available microarray platform.

Methods

Blood samples were collected from 121 females referred for diagnostic mammography following an initial suspicious screening mammogram. Diagnostic work-up revealed that 67 of these women had breast cancer while 54 had no malignant disease. Additionally, nine samples from six healthy female controls were included. Gene expression analyses were conducted using high density oligonucleotide microarrays. Pa

SUBMITTER: Aaroe J 

PROVIDER: S-EPMC2880427 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature