Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.

ABSTRACT:

Introduction

The risk of breast cancer to first degree relatives of breast cancer patients is approximately twice that of the general population. Breast cancer, however, is a heterogeneous disease and it is plausible that the familial relative risk (FRR) for breast cancer may differ by the pathological subtype of the tumour. The contribution of genetic variants associated with breast cancer susceptibility to the subtype-specific FRR is still unclear.

Methods

We computed breast cancer FRR for subtypes of breast cancer by comparing breast cancer incidence in relatives of breast cancer cases from a population-based series with known estrogen receptor (ER), progesterone receptor (PR) or human epidermal growth factor receptor 2 (HER2) status with that expected from the general po

SUBMITTER: Mavaddat N 

PROVIDER: S-EPMC2880431 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature