Recent advances in structure-functional studies of mitochondrial factor B.

ABSTRACT: Since the early studies on the resolution and reconstitution of the oxidative phosphorylation system from animal mitochondria, coupling factor B was recognized as an essential component of the machinery responsible for energy-driven ATP synthesis. At the phenomenological level, factor B was agreed to lie at the interface of energy transfer between the respiratory chain and the ATP synthase complex. However, biochemical characterization of the factor B polypeptide has proved difficult. It was not until 1990 that the N-terminal amino acid sequence of bovine mitochondrial factor B was reported, which followed, a decade later, by the report describing the amino acid sequence of full-length human factor B and its functional characterization. The present review summarizes the recent advances in

SUBMITTER: Belogrudov GI 

PROVIDER: S-EPMC2880480 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature