"Topological significance" analysis of gene expression and proteomic profiles from prostate cancer cells reveals key mechanisms of androgen response.

ABSTRACT:

Background

The problem of prostate cancer progression to androgen independence has been extensively studied. Several studies systematically analyzed gene expression profiles in the context of biological networks and pathways, uncovering novel aspects of prostate cancer. Despite significant research efforts, the mechanisms underlying tumor progression are poorly understood. We applied a novel approach to reconstruct system-wide molecular events following stimulation of LNCaP prostate cancer cells with synthetic androgen and to identify potential mechanisms of androgen-independent progression of prostate cancer.

Methodology/principal findings

We have performed concurrent measurements of gene expression and protein levels following the treatment using microarrays and iTRAQ prot

SUBMITTER: Vellaichamy A 

PROVIDER: S-EPMC2880599 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature