Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.

ABSTRACT: The peptide isosteres (10 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK228, largazole, and SAHA for inhibition of the class I HDACs 1, 2, 3, and 6.

SUBMITTER: Bowers AA 

PROVIDER: S-EPMC2880701 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature