Role of genetics in prediction of disease course and response to therapy.

ABSTRACT: The clinical course of Crohn's disease and ulcerative colitis is highly variable between patients, and this has therapeutic implications. A number of clinical features have been identified, which predict a mild or more severe outcome. However, several of these are subjective and/or not persistent over time. With the progress in genetics research in inflammatory bowel disease (IBD), genetic markers are increasingly being proposed to improve stratification of patients. Genetics have the major advantage of being stable over time and not prone to subjective interpretation. Nevertheless, none of the genetic variants associated with particular outcomes have shown sufficient sensitivity or specificity to have been implemented in daily management. Along the same line of thinking, pharmacogenetics

SUBMITTER: Vermeire S 

PROVIDER: S-EPMC2880773 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature