Enhanced estrogen-induced proliferation in obese rat endometrium.

ABSTRACT:

Objective

We tested the hypothesis that the proliferative estrogen effect on the endometrium is enhanced in obese vs lean animals.

Study design

Using Zucker fa/fa obese rats and lean control, we examined endometrial cell proliferation and the expression patterns of certain estrogen-regulated proproliferative and antiproliferative genes after short-term treatment with estradiol.

Results

No significant morphologic/histologic difference was seen between the obese rats and the lean rats. Estrogen-induced proproliferative genes cyclin A and c-Myc messenger RNA expression were significantly higher in the endometrium of obese rats compared with those of the lean control. Expression of the antiproliferative gene p27Kip1 was suppressed by estrogen treatment in both obese and l

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC2880878 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature