Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive systems analysis.

ABSTRACT:

Background

Rapidly characterizing the operational interrelationships among all genes in a given organism is a critical bottleneck to significantly advancing our understanding of thousands of newly sequenced microbial and eukaryotic species. While evolving technologies for global profiling of transcripts, proteins, and metabolites are making it possible to comprehensively survey cellular physiology in newly sequenced organisms, these experimental techniques have not kept pace with sequencing efforts. Compounding these technological challenges is the fact that individual experiments typically only stimulate relatively small-scale cellular responses, thus requiring numerous expensive experiments to survey the operational relationships among nearly all genetic elements. Therefore, a re

SUBMITTER: Facciotti MT 

PROVIDER: S-EPMC2880973 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature