Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.

ABSTRACT:

Background

Recent whole genome analysis and follow-up studies have identified many new risk variants for coeliac disease (CD, gluten intolerance). The majority of newly associated regions encode candidate genes with a clear functional role in T-cell regulation. Furthermore, the newly discovered risk loci, together with the well established HLA locus, account for less than 50% of the heritability of CD, suggesting that numerous additional loci remain undiscovered. Linkage studies have identified some well-replicated risk regions, most notably chromosome 5q31 and 11q23.

Methods

We have evaluated six candidate genes in one of these regions (11q23), namely CD3E, CD3D, CD3G, IL10RA, THY1 and IL18, as risk factors for CD using a 2-phase candidate gene approach directed at chromoso

SUBMITTER: Brophy K 

PROVIDER: S-EPMC2880976 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature