Characteristics of the early immune response following transplantation of mouse ES cell derived insulin-producing cell clusters.

ABSTRACT:

Background

The fully differentiated progeny of ES cells (ESC) may eventually be used for cell replacement therapy (CRT). However, elements of the innate immune system may contribute to damage or destruction of these tissues when transplanted.

Methodology/principal findings

Herein, we assessed the hitherto ill-defined contribution of the early innate immune response in CRT after transplantation of either ESC derived insulin producing cell clusters (IPCCs) or adult pancreatic islets. Ingress of neutrophil or macrophage cells was noted immediately at the site of IPCC transplantation, but this infiltration was attenuated by day three. Gene profiling identified specific inflammatory cytokines and chemokines that were either absent or sharply reduced by three days after IPCC trans

SUBMITTER: Boyd AS 

PROVIDER: S-EPMC2881030 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature