PhenoFam-gene set enrichment analysis through protein structural information.

ABSTRACT:

Background

With the current technological advances in high-throughput biology, the necessity to develop tools that help to analyse the massive amount of data being generated is evident. A powerful method of inspecting large-scale data sets is gene set enrichment analysis (GSEA) and investigation of protein structural features can guide determining the function of individual genes. However, a convenient tool that combines these two features to aid in high-throughput data analysis has not been developed yet. In order to fill this niche, we developed the user-friendly, web-based application, PhenoFam.

Results

PhenoFam performs gene set enrichment analysis by employing structural and functional information on families of protein domains as annotation terms. Our tool is designed

SUBMITTER: Paszkowski-Rogacz M 

PROVIDER: S-EPMC2881086 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature