High-throughput computational structure-based characterization of protein families: START domains and implications for structural genomics.

ABSTRACT: SkyLine, a high-throughput homology modeling pipeline tool, detects and models true sequence homologs to a given protein structure. Structures and models are stored in SkyBase with links to computational function annotation, as calculated by MarkUs. The SkyLine/SkyBase/MarkUs technology represents a novel structure-based approach that is more objective and versatile than other protein classification resources. This structure-centric strategy provides a multi-dimensional organization and coverage of protein space at the levels of family, function, and genome. The concept of "modelability", the ability to model sequences on related structures, provides a reliable criterion for membership in a protein family ("leverage") and underlies the unique success of this approach. The overall procedure

SUBMITTER: Lee H 

PROVIDER: S-EPMC2881152 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature