Robust unmixing of tumor states in array comparative genomic hybridization data.

ABSTRACT:

Motivation

Tumorigenesis is an evolutionary process by which tumor cells acquire sequences of mutations leading to increased growth, invasiveness and eventually metastasis. It is hoped that by identifying the common patterns of mutations underlying major cancer sub-types, we can better understand the molecular basis of tumor development and identify new diagnostics and therapeutic targets. This goal has motivated several attempts to apply evolutionary tree reconstruction methods to assays of tumor state. Inference of tumor evolution is in principle aided by the fact that tumors are heterogeneous, retaining remnant populations of different stages along their development along with contaminating healthy cell populations. In practice, though, this heterogeneity complicates interpretat

SUBMITTER: Tolliver D 

PROVIDER: S-EPMC2881397 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature