Finding metabolic pathways using atom tracking.

ABSTRACT:

Motivation

Finding novel or non-standard metabolic pathways, possibly spanning multiple species, has important applications in fields such as metabolic engineering, metabolic network analysis and metabolic network reconstruction. Traditionally, this has been a manual process, but the large volume of metabolic data now available has created a need for computational tools to automatically identify biologically relevant pathways.

Results

We present new algorithms for finding metabolic pathways, given a desired start and target compound, that conserve a given number of atoms by tracking the movement of atoms through metabolic networks containing thousands of compounds and reactions. First, we describe an algorithm that identifies linear pathways. We then present a new algorithm

SUBMITTER: Heath AP 

PROVIDER: S-EPMC2881407 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature