Characterization of tamulamides A and B, polyethers isolated from the marine dinoflagellate Karenia brevis.

ABSTRACT: Florida red tides occur as the result of blooms of the marine dinoflagellate Karenia brevis. K. brevis is known to produce several families of fused polyether ladder compounds. The most notable compounds are the brevetoxins, potent neurotoxins that activate mammalian sodium channels. Additional fused polyether ladder compounds produced by K. brevis include brevenal, brevisin, and hemibrevetoxin B, all with varying affinities for the same binding site on voltage-sensitive sodium channels. The structure elucidation and biological activity of two additional fused polyether ladder compounds containing seven fused ether rings will be described in this paper. Tamulamide A (MW = 638.30) and tamulamide B (MW = 624.29) were isolated from K. brevis cultures, and their structures elucidated using a c

SUBMITTER: Truxal LT 

PROVIDER: S-EPMC2881462 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature