TRPC1 channels are critical for hypertrophic signaling in the heart.

ABSTRACT:

Rationale

Cardiac muscle adapts to increase workload by altering cardiomyocyte size and function resulting in cardiac hypertrophy. G protein-coupled receptor signaling is known to govern the hypertrophic response through the regulation of ion channel activity and downstream signaling in failing cardiomyocytes.

Objective

Transient receptor potential canonical (TRPC) channels are G protein-coupled receptor operated channels previously implicated in cardiac hypertrophy. Our objective of this study is to better understand how TRPC channels influence cardiomyocyte calcium signaling.

Methods and results

Here, we used whole cell patch clamp of adult cardiomyocytes to show upregulation of a nonselective cation current reminiscent of TRPC channels subjected to pressure overloa

SUBMITTER: Seth M 

PROVIDER: S-EPMC2881555 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature