Effects of time, albuterol, and budesonide on the shape of the flow-volume loop in children with asthma.

ABSTRACT:

Background

Assessment of asthma through spirometric analysis in children is challenging because of often normal FEV(1) values.

Objective

We used Mead's slope ratio (SR; (dV /dV)/(V /V)) to analyze the shape of the flow-volume loop.

Methods

We analyzed the effects of time, albuterol, and budesonide on FEV(1), FEV(1)/forced vital capacity (FVC) ratio, forced expiratory flow from 25% to 75% of expired volume, and Mead's SR both early (between 75% and 50% of FVC, SR61) and late (between 75% and 50% of FVC, SR35) in exhalation in the Childhood Asthma Management Program cohort at baseline, 4 months, and the end of the study in participants who received either inhaled placebo or budesonide twice daily.

Results

In the placebo group both SR61 and SR35 improved over time

SUBMITTER: Patel AC 

PROVIDER: S-EPMC2881659 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature