EEG-fMRI: adding to standard evaluations of patients with nonlesional frontal lobe epilepsy.

ABSTRACT:

Objective

In patients with nonlesional frontal lobe epilepsy (FLE), the delineation of the epileptogenic zone is difficult. Therefore these patients are often not considered for surgery due to an unclear seizure focus. The aim of this study was to investigate whether EEG-fMRI can add useful information in the preoperative evaluation of these patients.

Methods

Nine nonlesional FLE patients were studied with EEG-fMRI using a 3 T scanner. Spike-related blood oxygen level dependent (BOLD) signal changes were compared to the topography of the spikes and to PET and SPECT results if available. The structural MRIs were reviewed for subtle abnormalities in areas that showed BOLD responses. For operated patients, postoperative resection and histology were compared to BOLD responses.

SUBMITTER: Moeller F 

PROVIDER: S-EPMC2881856 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature