Control of the SOST bone enhancer by PTH using MEF2 transcription factors.

ABSTRACT:

Unlabelled

Expression of the osteocyte-derived bone formation inhibitor sclerostin in adult bone requires a distant enhancer. We show that MEF2 transcription factors control this enhancer and mediate inhibition of sclerostin expression by PTH.

Introduction

Sclerostin encoded by the SOST gene is a key regulator of bone formation. Lack of SOST expression is the cause for the progressive bone overgrowth disorders sclerosteosis and Van Buchem disease. We have previously identified a distant enhancer within the 52-kb Van Buchem disease deletion downstream of the SOST gene that is essential for its expression in adult bone. Furthermore, we and others have reported that SOST expression is suppressed by PTH. The aim of this study was to identify transcription factors involved in SOS

SUBMITTER: Leupin O 

PROVIDER: S-EPMC2882185 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature