Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters.

ABSTRACT: Herein we report that simple Lewis acids catalyze the hydroarylation of benzylidene malonates with phenols. Ultimately, 3,4-disubstituted dihydrocoumarins are obtained via a hydroarylation-lactonization sequence. Moreover, the dihydrocoumarins are formed with a high degree of diastereoselectivity favoring the trans stereoisomer.

SUBMITTER: Duan S 

PROVIDER: S-EPMC2882201 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature